National Laboratories Biomanufacturing

Proteins/Enzymes

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Capabilities and Facilities

Environmental Molecular Sciences Laboratory (PNNL)

Structural Biology and Imaging Resources at Synchrotron and Neutron Facilities (ANL, BNL, LBNL, ORNL, SLAC)

Laboratory of Biomolecular Structure — CryoEM Facility (BNL)

PHENIX: Consortium and Software for Computational Crystallography (LBNL)

Scattering Program for Investigating the Structure and Dynamics of Composite and Complex Material, Including Polymers, Films, and Fibers (BNL)

PMedIC: Precision Medicine Innovation Co-Laboratory (PNNL)

Intellectual Property

Engineering Bacterial Systems to Shield Toxicity During Non-native Protein Expression and Purification (LLNL)

Thermoacidophilic Enzyme Systems (INL)

Upcycling Novel Bio-derived Chemical Building Blocks from PET (NREL)

Methods and Devices for Protein Assays (SNL)

NIMS-based Multiplexed Enzymatic Assays (LBNL, SNL)

Cell-Free System for Synthesizing Membrane Proteins (ANL)

Flex Plate: Innovative Protein Crystallization Tool (BNL)

Enzymatic Cascade Bioreactor (SNL)

Armored Enzyme Nanoparticles (PNNL)

Nell1-mediated Regeneration of Skeletal Muscle in Wound Healing and Muscle Dystrophies (ORNL)

A Highly Stable Plant-Fungal Peroxidase Engineered for Enhanced Lignin Conversion (LBNL, SNL)

Improved T7 Cloning and Expression Vectors (BNL)

JTherm Glycoside Hydrolases for Deconstruction of Lignocellulosic Biomass (LBNL, SNL)

Repair of Cardiac Muscles and Blood Vessels Using the Cell Differentiation Signaling Protein Nell1 (ORNL)

Designable Peptoid Nanotubes (PNNL)

Thermophilic Endoglucanase Enzymes Engineered for Increased Activity (SNL)

NanoPOTS: Nanodroplet Processing in One pot for Trace Samples (PNNL)

Broadly pH-tolerant Cellulase Enzymes (LBNL, SNL)

Halophilic and Thermostable Cellulases (LBNL, SNL)

Artificial Metalloproteins for Producing New Chemicals and Materials (LBNL)

Promoter Useful for High Expression of Heterologous Genes in Aspergillus Niger (PNNL, SNL, LBNL)

Identification of Gene Targets for Improved Heterologous Enzyme Production in Aspergillus Niger (PNNL, SNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service